ARL 67156 trisodium salt 是ATP的新合成类似物，起选择性CD39（胞外ATPase）抑制剂的作用。此外，研究表明ARL 67156三钠盐还可以作为嘌呤受体P2X和P2T的弱拮抗剂，并作为P2u的激动剂。在受体的药理学分类中观察到的一个常见问题是拮抗剂和激动剂对所用测定组织的酶促降解的敏感性，ARL 67156三钠盐可能会解决该问题。据报道，ARL 67156三钠盐还通过抑制去磷酸化作用来增强UTP，ATP-γ-S和ATP对嘌呤受体的作用。此外，ARL 67156三钠盐可用作确定核 ARL 67156 trisodium salt is a newly synthesized analog of ATP which functions as a selective CD39 (ecto-ATPase) inhibitor. In addition, studies suggest that ARL 67156 trisodium salt also acts as a weak antagonist for the purinoceptors P2X and P2T and as an agonist for P2u. A common problem observed in the pharamacological classification of receptors is the susceptibility of antagonists and agonists to enzymatic degradation by the assay tissue used, which ARL 67156 trisodium salt may possibly resolve. It has been reported that ARL 67156 trisodium salt also potentiates the effects of UTP, ATP-γ-S, and ATP on purinoceptors via inhibiting dephosphorylation. Furthermore, ARL 67156 trisodium salt can be used as a probe to determine the action of nucleotides and in the classification of purinoceptors. ARL 67156 trisodium salt has a pIC50 = 4.62 and 5.1 in human blood and rat vas deferens, respectively.
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ARL 67156 trisodium salt
CAS number：160928-38-1 molecular formula：C15H24Br2N5O12P3
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Specs
| Chinese alias | ARL 67156 三钠盐 | ||
| English alias | ARL 67156 | 6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP | FPL 67156 | FPL-67156 | [dibromo-[[[(2R,3S,4R,5R)-5-(6-diethylaminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid | DTXSID301017960 | ||
| CAS number | 160928-38-1 | molecular formula | C15H24Br2N5O12P3 |
| molecular weight | 719.11 g/mol | Exact mass | - |
| PSA | 247.000 Ų | logp | -2.700 |
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