8（S）-HETE是嗜中性粒细胞的多不饱和脂肪酸趋化剂，是合成类二十烷酸家族（称为白三烯）的中间体。已经观察到该化合物在人类嗜中性粒细胞，佛波酯处理的小鼠表皮中以及通过肝微粒体细胞色素P-4503是生物合成的。已经观察到8（S）-HETE调节大鼠角膜中的上皮细胞迁移。该化合物还被认为是花生四烯酸在角膜伤口愈合中的关键成分。有证据表明8（S）-HETE激活PPARα和PKC。 8(S)-HETE is a polyunsaturated fatty acid chemotactic for neutrophils and an intermediate in the synthesis of the family of eicosanoids known as leukotrienes. The compound has been observed to be biosynthesized in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-4503. 8(S)-HETE has been observed to regulate epithelial cell migration in the rat cornea. The compound has also been recognized as the key component of arachidonic acid in corneal wound healing. Evidence demonstrates 8(S)-HETE activates PPARα and PKC.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
8(S)-HETE
Dangerous GoodsCAS number：98462-03-4 molecular formula：C20H32O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | NLUNAYAEIJYXRB-VYOQERLCSA-N | 8(S)-HETE | 8(S)-hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid | 8(S-hydroxy-(5Z, 9E, 11Z, 14Z)-eicosatetraenoic acid | 8(S)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid, ~100 mug/mL in ethanol, ~98% (HPLC) | GTPL2679 | ||
| CAS number | 98462-03-4 | molecular formula | C20H32O3 |
| molecular weight | 320.47 g/mol | Exact mass | - |
| PSA | 57.500 Ų | logp | 5.200 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
WGK Germany：
3
Personal protective equipment：
Eyeshields， Faceshields， full-face respirator (US)， Gloves， multi-purpose combination respirator cartridge (US)， type ABEK (EN14387) respirator filter
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
