Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model. An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
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Myriocin
Dangerous GoodsCAS number：35891-70-4 molecular formula：C21H39NO6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 6-EICOSENOIC ACID, 2-AMINO-3,4-DIHYDROXY-2-(HYDROXYMETHYL)-14-OXO-, (2S,3R,4R,6E) | SR-05000002333-3 | UNII-YRM4E8R9ST | VRP | YRM4E8R9ST | F85634 | NCGC00163597-04 | (2S,3R,4R,E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid | (E,2S,3R, | ||
| CAS number | 35891-70-4 | molecular formula | C21H39NO6 |
| molecular weight | 401.54 g/mol | Exact mass | - |
| PSA | 141.000 Ų | logp | -0.100 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US),Eyeshields,Faceshields,Gloves
RTECS：
JX3890000
UN Number：
2811
Production methods and uses
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downstream information
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MSDS
Found 0 shareMSDS
