compound introduction
β-咔啉-3-羧酸乙酯是一种可从人尿液提取物中分离出来的多环芳族小分子，证明其在GABA | A |受体上作为苯二氮卓类活性的部分反向激动剂而具有抗焦虑作用。具有3位羰基官能度的β-咔啉衍生物已证明与与脑电解损伤相关的效果相当，可诱发惊厥和血管生成。β-咔啉-3-羧酸乙酯表明地西epa从苯并二氮杂pine结合位点置换。 Ethyl β-carboline-3-carboxylate is a polyaromatic small molecule isolable from human urine extracts, demonstrating anxiogenic effects as a partial inverse agonist of benzodiazepine activity at the GABA|A|receptors. β-carboline derivatives with a 3-position carbonyl functionality have demonstrated induction of convulsions and anxiogenesis comparable to the effects associated with cerebral electrolytic lesions. Ethyl β-carboline-3-carboxylate demonstrates displacement of diazepam from the benzodiazepine binding site.
