compound introduction
Isoliquiritin apioside (ISLA, ILA) 是一种分离自 Glycyrrhizae radix rhizome (GR) 的成分，可显著地降低PMA诱导的 matrix metalloproteinase (MMP) 的活性增加并抑制了PMA-诱导 mitogen-activated protein kinase (MAPK) 和 NF-κB 的活化。Isoliquiritin apioside 在恶性癌细胞和EC中具有抗转移和抗血管生成的能力，并且没有细胞毒性。 Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.
