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ABT-263

CAS number:923564-51-6    molecular formula:C47H55ClF3N5O6S3

overview

compound introduction

产品介绍: Navitoclax (ABT-263)是一种有效的Bcl-xL,Bcl-2和Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。 Navitoclax (ABT-263) 是有效的 Bcl-2 抑制剂,可与Bcl-xL,Bcl-2, Bcl-w等多种Bcl-2家族蛋白结合,Ki 值小于 1 nM。 Shipped at 4°C. Store at -20°C. Store under desiccating conditions. Product description Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.

Specs

Chinese alias4-[4-[[2-(4-氯苯基)-5,5-二甲基-1-环己烯-1-基]甲基]-1-哌嗪基]-N-[[4-[[((R)-3-(4-吗啉基)-1-[((苯硫基)甲基]丙基]氨基]-3-[((三氟甲基)磺酰基]苯基]磺酰基]苯甲酰胺', | 生根粉263
English aliasNavitoclax | ABT263 | (R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
CAS number923564-51-6molecular formulaC47H55ClF3N5O6S3
molecular weight974.61 g/molExact mass≥98%
PSA170.000 Ųlogp9.6

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