CAS number：852808-04-9 molecular formula：C42H45ClN6O5S2
ABT-737是 Bcl-xL, Bcl-2 和 Bcl-w抑制剂，EC50分别为78.7 nM，30.3 nM和197.8 nM。对Mcl-1， Bcl-B 和 Bfl-1无抑制性。A selective inhibitor of Bcl-2 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. A selective inhibitor of Bcl-2
| Chinese alias | - | ||
| English alias | 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide | NCGC00253562-01 | HY-50907 | 4-{4-[(4'-chloro[biphenyl]-2-yl)methyl]piperazin-1-yl}-N-[(4-{[(2R)-4-(di | ||
| CAS number | 852808-04-9 | molecular formula | C42H45ClN6O5S2 |
| molecular weight | 813.43 g/mol | Exact mass | - |
| PSA | 164.000 Ų | logp | 9 |
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