截短侧耳素是有效的二萜类抗生素，对革兰氏阳性细菌具有活性。该抗生素于1951年从白灵菇属中分离出来。|通过结晶和生化研究证明，截短侧耳素通过阻断底物与核糖体肽基转移酶中心的供体位点和受体位点的结合而起作用，从而抑制了该菌的生长。肽键形成。该化合物与其他化合物的交叉电阻最小，这归因于其作用方式。截短侧耳素靶向广泛的病原体，已用于皮肤和呼吸道感染研究。 Pleuromutilin is a potent diterpene antibiotic with activity against gram-positive bacteria. The antibiotic was isolated in 1951 from the genus|Pleurotus.|It has been demonstrated through crystallization and biochemical research that Pleuromutilins acts by blocking substrate binding to the donor site and acceptor site of the ribosome's peptidyl-transferase center, which results in inhibition of the peptide bond formation. The compound encounters minimum cross-resistance with other compounds, which is attributed to its mode of action. Pleuromutilins targets a wide spectrum of pathogens and has been used in skin and respiratory tract infection studies.
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Pleuromutilin
Dangerous GoodsCAS number：125-65-5 molecular formula：C22H34O5
overview
compound introduction
Specs
| Chinese alias | 泰妙菌素 | (3aS,4R,5S,6S,8R,9R,9aR,12R)-5-羟基-4,6,9,12-四甲基-1-氧代-6-乙烯基十氢-3a,9-丙环戊[8]-2-羟基乙酸8-基 | ||
| English alias | PLEUROMULIN | (3aS,4R,5S,6S,8R,9R,9aR,12R)-5-Hydroxy-4,6,9,12-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl 2-hydroxyacetate | HY-N2301 | [(2R,3S,4S,6R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8 | ||
| CAS number | 125-65-5 | molecular formula | C22H34O5 |
| molecular weight | 378.51 g/mol | Exact mass | ≥95% |
| PSA | 83.800 Ų | logp | 3.500 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS07
Signal word：
Danger
Hazard Statement：
H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P284: 如果通风不良，请佩戴呼吸防护装置。 P2
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MSDS
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