compound introduction
Beauvericin 是一种环六肽镰刀菌毒素，具有杀虫、抗菌、抗癌、抗病毒和细胞毒活性。Beauvericin 通过产生 DNA 断裂、染色体畸变和微核，造成细胞的遗传毒性，并抑制 PI3K/AKT 通路诱导细胞凋亡 (apoptosis)，从而抑制 HCC 的生长。此外，Beauvericin 通过抑制淋巴细胞增殖和干扰人单核细胞向巨噬细胞的分化过程，来影响免疫功能。 Beauvercin is a mycotoxin within the enniatin family produced by Fusarium sp. As an enniatin mycotoxin, Beauvercin has been reported to affect mitochondria through depletion of the transmembrane potential, induction of swelling and in decreasing calcium retention capacity. A screening method for quantification of Beauvercin and other mycotoxins in aqueous environmental samples has been described involving solid-phase extraction, liquid chromatography and mass spectometry. An enniatin family mycotoxin
