CAS number：469-83-0 molecular formula：C20H28O3
Cafestol 是咖啡特有的一种二萜，可靶向 AP-1 抑制ERK，有化学预防、抗肿瘤、保肝、抗氧化和抗炎作用。它通过抑制NF-kB 活化途径强烈的抑制 PGE2的产生，还抑制 LGE 激活的 RAW264.7 细胞中的PGE2产生和环氧合酶(COX-2)的 mRNA 表达。 CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
| Chinese alias | (3bS,5aS,7R,8R,10aR,10bS)-7-(羟甲基)-10b-甲基-3b,4,5,6,7,8,9,10,10a,10b,11,12-十二烷基-5a,8-甲基环庚[5,6]萘[2,1-b]呋喃-7-醇 | 咖啡油醇 | ||
| English alias | SR-05000002204 | CHEBI:3291 | cafesterol | (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol | CCRIS 1518 | AC465T6Q6W | UNII-AC465T6Q6W | ||
| CAS number | 469-83-0 | molecular formula | C20H28O3 |
| molecular weight | 316.43 g/mol | Exact mass | ≥98% |
| PSA | 53.600 Ų | logp | 3.3 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
