储存在+ 4°C。该产品最多可存储12个月。 CGP 57380 是强效的MNK1抑制剂，其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。CGP 57380 可上调 β-catenin 并加强辐射诱导的凋亡。 Store at +4°C. The product can be stored for up to 12 months. application： CGP 57380 has been used: as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells. Biochemical mechanism: CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT). CGP 57380 is a cell-permeable selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1).
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CGP 57380
Dangerous GoodsCAS number：522629-08-9 molecular formula：C11H9FN6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | NSC 741567 | SR-02000000869 | A902707 | BISBENTIAMINE [MI] | NCIOpen2_009023 | SCHEMBL16714452 | NCGC00162380-01 | HMS3648M14 | C75450 | HMS3653G22 | Q27087429 | AKOS024457265 | SDCCGSBI-0086774.P002 | HMS3677D16 | NCGC00162380-02 | HMS3673K05 | BDBM50298 | ||
| CAS number | 522629-08-9 | molecular formula | C11H9FN6 |
| molecular weight | 244.23 g/mol | Exact mass | - |
| PSA | 92.500 Ų | logp | 2.300 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H319: 引起严重眼睛刺激
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
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MSDS
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