Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC 50 of 9.76 μM. In Vitro Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+)-induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by Chebulagic acid treatment in the EA.hy926 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Chebulagic acid
CAS number：23094-71-5(DMSO) molecular formula：C41H30O27
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| Chinese alias | 诃子酸 | ||
| English alias | - | ||
| CAS number | 23094-71-5(DMSO) | molecular formula | C41H30O27 |
| molecular weight | 954.66 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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