达福普汀是ostreogyrcin A的半合成类似物（维吉尼霉素 M，维吉尼霉素 IIA，维吉尼霉素 A），是通过在ostreogyrcin的2-吡咯啉组中添加二乙氨基乙基硫醇，然后氧化成砜而形成的。结构上的变化为疏水性更高的化合物提供了易于电离的基团，用于生成盐。达福普汀与奎奴普丁（70:30）协同组合用于商业用途。关于达福普汀单独的合成，生物学或抗生素活性的公开数据很少，但是该联合产品非常有效，包括针对抗生素抗性菌株的活性。 Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
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Dalfopristin
Dangerous GoodsCAS number：112362-50-2 molecular formula：C34H50N4O9S
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Specs
| Chinese alias | - | ||
| English alias | (6R,7S,10R,11R,12E,17E,19E,21S)-6-[2-(diethylamino)ethylsulfonyl]-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone | DALFOPRISTIN [INN] | DALFOPRISTIN [WHO-DD] | ||
| CAS number | 112362-50-2 | molecular formula | C34H50N4O9S |
| molecular weight | 690.85 g/mol | Exact mass | - |
| PSA | 185.000 Ų | logp | 2.2 |
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WGK Germany：
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