3,7-Dihydroxyflavone (Resogalangin) 是一种黄酮类植物雌激素 (phytoestrogen，可以从沙参属植物中分离得到。3,7-Dihydroxyflavone 是雌激素受体的调节剂，是人类孕酮代谢酶 AKR1C1 和真菌 17β-羟基类固醇脱氢酶的抑制剂和氧化还原方向的抑制剂 (IC50 分别为 0.6 和 6.0 μM)。3,7-Dihydroxyflavone 是人血清白蛋白 (HSA) 的荧光结合底物，激发波长分别为 370 nm (pH 7.4) 和 350 nm (pH 3.5)，发射波长为 515 nm。 3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm.
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3,7-Dihydroxyflavone
CAS number：492-00-2 molecular formula：C15H10O4
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Specs
| Chinese alias | 3,7-二羟基-2-苯基-4H-苯并吡喃-4-酮 | ||
| English alias | Resogalangin | 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one | ||
| CAS number | 492-00-2 | molecular formula | C15H10O4 |
| molecular weight | 254.24 g/mol | Exact mass | ≥97% |
| PSA | 66.800 Ų | logp | 3.000 |
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