compound introduction
Tyrphostin AG 30是一种特异于c-ErbB的有效蛋白酪氨酸激酶（PTK）抑制剂。已显示该化合物抑制c-erbB在原代成红细胞中激活STAT5。已经观察到该化合物在结肠癌细胞中引起分化表型的诱导，这与PTK活性和酪氨酸磷酸化的显着降低有关。与其他Tyrphostin不同，Tyrphostin AG 30无法调节U-937单核细胞中NO依赖性基因的表达。 Tyrphostin AG 30 is a potent protein tyrosine kinase (PTK) inhibitor specific for c-ErbB. the compound has been shown to inhibit activation of STAT5 by c-erbB in primary erythroblasts. The compound has been observed to cause induction of the differentiated phenotype in colon cancer cells which is associated with a marked decrease in PTK activity and tyrosine phosphorylation. Unlike other Tyrphostins, Tyrphostin AG 30 was unable to regulate expression of NO-dependent genes in U-937 monocytic cells.
