compound introduction
依普罗沙坦是咪唑丙烯酸血管紧张素II受体拮抗剂的原型，具有抗高血压特性。它以两种方式作用于肾素-血管紧张素系统，以降低总外周阻力。首先，它阻断血管紧张素II与血管平滑肌中AT1受体的结合，从而引起血管扩张。其次，它抑制交感性去甲肾上腺素的产生，进一步降低血压。 Eprosartan is a prototype of the imidazoleacrylic acid angiotensin II receptor antagonist which exhibits antihypertensive properties. It acts on the renin-angiotensin system in two ways to decrease total peripheral resistance. First, it blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.
