N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).一种Cox-2抑制剂。 N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g). A Cox-2 inhibitor.
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N-tert-Butyl-α-phenylnitrone
Dangerous GoodsCAS number：3376-24-7 molecular formula：C11H15NO
overview
compound introduction
Specs
| Chinese alias | N-叔丁基苯硝酮 | ||
| English alias | PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(tert-butyl | ||
| CAS number | 3376-24-7 | molecular formula | C11H15NO |
| molecular weight | 177.24 g/mol | Exact mass | ≥95% |
| PSA | 28.800 Ų | logp | 1.300 |
numbering system
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physicochemical properties
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Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
TX1760000
Production methods and uses
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MSDS
Found 1 shareMSDS
3376-24-7 | N-benzyliden-tert-butylamine N-ether.pdf
