林可霉素是一种极性的水溶性广谱抗生素，最早于1962年由Upjohn的研究人员从[Streptomyces licolnensis]中分离出来。林可霉素是一种独特的结构类型，即林可酰胺，它含有稀有氨基酸4-丙基-N-甲基脯氨酸，与同样稀有的氨基甲基硫代-章吡喃糖苷偶联。经常将林可霉素和半合成类似物误认为是氨基糖苷，但几乎没有或没有结构相似性。林可霉素是一种广谱抗生素，具有抗厌氧细菌和原生动物的活性。林可霉素通过与23S核糖体亚基结合而起作用，从而阻止了蛋白质的合成。对林可霉素进行了广泛的研究，引用了7,0 Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from|Streptomyces licolnensis|by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N- methylproline, coupled to an equally rare aminomethylthio- octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
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Lincomycin
CAS number：154-21-2 molecular formula：C18H34N2O6S
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Specs
| Chinese alias | 洁霉素 | 6,8-二脱氧-6-(1-甲基-4-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-D-赤式-alpha-D-半乳辛吡喃糖苷 | ||
| English alias | methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside | ||
| CAS number | 154-21-2 | molecular formula | C18H34N2O6S |
| molecular weight | 406.54 g/mol | Exact mass | - |
| PSA | 148.000 Ų | logp | 0.2 |
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RTECS：
RH6314000
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