CAS number：107761-24-0 molecular formula：C19H18N2O3S
ST638是一种蛋白质酪氨酸激酶抑制剂（IC | 50 | = 370 nM），也可以抑制HGF诱导的肝细胞中MAP激酶激活。ST638还显示出抑制人类嗜中性粒细胞中PC-PLD（磷脂酶D）的活性。该产品减少了中性粒细胞中过钒酸盐诱导的O2⋅产生。 ST638 is a protein tyrosine kinase inhibitor (IC|50|= 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes. ST638 has also shown to inhibit PC-PLD (phospholipase D) activity in human neutrophils. This product decreases the O2? production induced by pervanadate in neutrophils.
| Chinese alias | - | ||
| English alias | Q27164644 | (Z)-2-cyano-3-(3-ethoxy-4-hydroxy-5-(phenylthiomethyl)phenyl)acrylamide | DTXSID701147014 | 2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]- | alpha-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide | 2-cyano-3- | ||
| CAS number | 107761-24-0 | molecular formula | C19H18N2O3S |
| molecular weight | 354.4 | Exact mass | - |
| PSA | 122 | logp | 3.1 |
| CAS | 107761-24-0 |
| HMDB ID | HMDB0248195 |
| Wikidata | Q27164644 |
| PubChem CID | 5276 |
| DSSTox Substance ID | DTXSID701147014 |
| European Community (EC) Number | 634-605-1 |
| XLogP3 | XLogP3-AA: 3.1 |
| 复杂性 | 522 |
| Exact Mass | 354.10381361 |
| 形式电荷 | 0 |
| 重原子计数 | 25 |
| Molecular Weight | 354.4 |
| Monoisotopic Mass | 354.10381361 |
| 可旋转键计数 | 7 |
| 氢键供体计数 | 2 |
| 氢键受体计数 | 5 |
| 共价键单元计数 | 1 |
| 同位素原子计数 | 0 |
| 拓扑极性表面积 | 122 Ų |
| 定义键立体中心计数 | 0 |
| 定义原子立体中心计数 | 0 |
| 未定义键立体中心计数 | 1 |
| 未定义原子手性中心计数 | 0 |
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