4-甲基伞形酮钠盐是透明质酸（HA）合成的选择性抑制剂。HA是恶性肿瘤转移中的主要成分。研究表明，在4-甲基伞形酮钠盐存在下，细胞的增殖，迁移和生长受到抑制，而细胞凋亡被诱导。另外，成纤维细胞细胞系NIH / 3T3的运动性和细胞生长受到抑制。人们认为4-甲基伞形酮钠盐可通过消耗HA合成的常用底物UDP-葡萄糖醛酸来起抑制剂的作用。还认为4-甲基伞形酮钠盐可以抑制HA合酶的表达。 4-Methylumbelliferone sodium salt is a selective inhibitor of Hyaluronan (HA) synthesis. HA is a major component in the metastasis of malignant tumors. Studies indicate that in the presence of 4-Methylumbelliferone sodium salt cell proliferation, migration, and growth are inhibited, while apoptosis is induced. In addition, the motility and cell growth was inhibited in fibroblast cell line NIH/3T3 . 4-Methylumbelliferone sodium salt is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis. It is also believed that 4-Methylumbelliferone sodium salt can suppress the expression of HA-synthase.
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4-Methylumbelliferone sodium salt
CAS number：5980-33-6 molecular formula：C10H7O3・Na
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| Chinese alias | 羟甲香豆素 钠盐 | β-甲基伞形酮 | 7-羟基-4-甲基香豆素 | ||
| English alias | FT-0693406 | 4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline | Methyl 4 ombelliferone sodee [French] | sodium 4-methyl-2-oxo-2H-chromen-7-olate | AKOS006272675 | 4-Methylumbelliferone sodium salt | LM 94 sodium | UNII-86UG9WCF3N | 4-methyl um | ||
| CAS number | 5980-33-6 | molecular formula | C10H7O3・Na |
| molecular weight | 198.15 g/mol | Exact mass | ≥98% |
| PSA | 49.400 Ų | logp | - |
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