Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC 50 of 13.64 μM . In Vitro Sulfuretin is one of the main flavonoids produced by Rhus verniciflua . Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Pathogen-free male BALB/c mice (7-8 weeks old) Dosage: 40 μg/kg Administration: A single intraperitoneal injection was administered 2 h after the last OVA challenge Result: Suppressed OVA-induced chemotaxis and airway inflammation. Form:Solid
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Sulfuretin
CAS number：120-05-8 molecular formula：C15H10O5
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 3',4',6-TRIHYDROXYBENZALCOUMARANONE | 3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-, (2Z)- | HMS2270H03 | (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-benzofuran-3-one | SCHEMBL634006 | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6 | ||
| CAS number | 120-05-8 | molecular formula | C15H10O5 |
| molecular weight | 270.24 g/mol | Exact mass | ≥98% |
| PSA | 87.000 Ų | logp | 2.5 |
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