CAS number：64091-91-4 molecular formula：C10H13N3O2
NNK 是一种尼古丁亚硝化衍生物。NNK 通过激活 ERK1/2 和 PKCα， 同时在 Ser70 刺激 Bcl2 磷酸化，以及在Thr58 和 Ser62 刺激 c-Myc。NNK 能诱导人肺癌细胞的存活和增殖。NNK 可用于构建肺癌小鼠模型。 Product Describtion: NNK is a nitrosate derivative of nicotine. NNK activates ERK1/2 and PKC α， Simultaneously stimulating Bcl2 phosphorylation in Ser70 and c-Myc in Thr58 and Ser62. NNK can induce the survival and proliferation of human lung cancer cells. NNK can be used to construct a lung cancer mouse model.
| Chinese alias | 4-(甲基亚硝氨基)-1-(3-吡啶基)-1-丁酮 | 4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁酮 | ||
| English alias | 4-Methylnitrosamino-1,3-pyridyl-1-butanone | CHEBI:32692 | 4-n-nitrosomethylamino-1-3-pyridyl-1-butanone | FT-0616837 | CAS-64091-91-4 | N-methyl-N-(4-oxo-4-pyridin-3-ylbutyl)nitrous amide | SCHEMBL454516 | 1-Butanone, 4-(methylnitrosamino)-1-(3-pyridyl)- | ||
| CAS number | 64091-91-4 | molecular formula | C10H13N3O2 |
| molecular weight | 207.23 g/mol | Exact mass | - |
| PSA | 62.600 Ų | logp | 0.800 |
No numbering system information yet
No physical and chemical property information yet
No production method and use information yet
No upstream information yet
No downstream information yet
