AICA-核糖5'-磷酸是膜可渗透性AICA-核糖的单磷酸化类似物，其模仿AMP并充当AMPK（AMP激活的蛋白激酶）激活剂。AICA-核糖5'-磷酸盐显示出其母体衍生物的相似作用，包括刺激某些骨骼肌细胞系中的葡萄糖转运。 5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖基 5′——单磷酸盐 (AICAR) 是嘌呤生物合成的天然代谢中间体，通常存在于所有生物中。它是由琥珀酰-AICAR (SAICAR) 在腺苷酸琥珀酸裂解酶 (ASL) 的帮助下产生的。 应用： 5-氨基咪唑-4-甲酰胺-1-β- D -呋喃核糖基 5′-研究中使用了单磷酸来探索 9 种他汀类药物在乳腺癌和胶质母细胞瘤中的抗癌作用；AICAR 单磷酸盐是一种模拟 AMP 的细胞渗透性 AICAR 的 5''-磷酸化类似物。AICAR 是一种单磷酸腺苷 (AMP) 激活的蛋白激酶 (AMPK) 激活剂/激动剂。 AICA-Riboside, 5′-Phosphate is a monophosphorylated analog of the membrane permeable AICA-Riboside that mimics AMP and behaves as an AMPK (AMP-activated protein kinase) activator. AICA-Riboside, 5′-Phosphate displays similar effects of its parent derivative including stimulating glucose transport in certain skeletal-muscle cell lines. 5-aminoimidazole-4-formamide-1-β-d-ribofuran 5 '-monophosphate (AICAR) is a natural metabolic intermediate in purine biosynthesis, commonly found in all organisms. It is produced by succinyl-Aicar (SAICAR) with the help of adenylate succinase (ASL). Application： 5-aminoimidazole-4-formamide-1-β-D-ribofuranyl 5 '-monophosphate was used in the study to explore the anticancer effects of nine statins in breast cancer and glioblastoma; AICAR monophosphate is a 5 "-phosphorylated analog of cellular permeable AICAR that mimics AMP. AICAR is an adenosine monophosphate (AMP) activated protein kinase (AMPK) activator/agonist.
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AICA-Riboside, 5′-Phosphate
Dangerous GoodsCAS number：3031-94-5 molecular formula：C9H15N4O8P
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| Chinese alias | N1-(β-D-5'-磷酸呋喃糖基)-5-氨基咪唑-4-甲酰胺 | AICAR 单磷酸 | ||
| English alias | NSC 283955 | NSC 292227 | ZMP | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide | 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide | F0X88YW0YK | Z-nucleotide | 5-Aminoimidazole-4-carboxamide-1-?-D-Ribofuranosyl 5'-Monophosphate | EINECS 2 | ||
| CAS number | 3031-94-5 | molecular formula | C9H15N4O8P |
| molecular weight | 338.21 g/mol | Exact mass | ≥95% |
| PSA | 203.000 Ų | logp | -3.800 |
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WGK Germany：
3
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MSDS
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3031-94-5 | 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate.pdf
