CAS number：130495-35-1 molecular formula：C22H26N2O3·HCl
介绍： SKF-96365 hydrochloride 是一种有效的 TRP channel 阻滞剂和 SOCE (store-operated Ca2+ entry) 抑制剂。SKF-96365 hydrochloride 可显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流，显著延长 QTc 间期。SKF-96365 hydrochloride 通过诱导结直肠癌细胞的细胞周期阻滞和凋亡 (apoptosis) 而显示出强大的抗肿瘤活性。 应用： SKF-96365已用作：人类足细胞中的非选择性瞬时受体电位6 (TRPC6)，阻滞剂神经元中的库操纵性Ca2+内流拮抗剂，小鼠中的瞬时受体电位3 (TRPC3)阻滞剂。
| Chinese alias | - | ||
| English alias | S-175 | NCGC00260374-01 | CCG-268677 | 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride | AKOS022180729 | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,1 | ||
| CAS number | 130495-35-1 | molecular formula | C22H26N2O3·HCl |
| molecular weight | 402.92 g/mol | Exact mass | 10mM in DMSO |
| PSA | 45.500 Ų | logp | - |
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