CAS number：109581-93-3 molecular formula：C44H69NO12 · H2O
Tacrolimus monohydrate (FK506 monohydrate) 是大环内酯类化合物，Tacrolimus monohydrate 与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶 (calcineurin phosphatase)，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 Application FK-506 monohydrate has been used: as an immunosuppressive agent in coculture medium to study the effect of immunologic reaction as a calcineurin inhibitor, in anhydrous Me2SO solution to treat retinal pigment epithelial cells to measure possible cytotoxicity
| Chinese alias | FK-506一水合物 | FK-506 一水合物 | 他克莫司 一水合物 | 藤霉素一水合物 | ||
| English alias | D00107 | Tacrolimus, Pharmaceutical Secondary Standard; Certified Reference Material | TACROLIMUS [USP-RS] | TACROLIMUS MONOHYDRATE [WHO-DD] | FK 506 | TACROLIMUS [ORANGE BOOK] | TACROLIMUS MONOHYDRATE | WM0HAQ4WNM | FK-506 monohydrate, >=98% (HPLC) | Pro | ||
| CAS number | 109581-93-3 | molecular formula | C44H69NO12 · H2O |
| molecular weight | 822.03 g/mol | Exact mass | ≥80%(HPLC) |
| PSA | 179.000 Ų | logp | - |
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