蟾蜍灵（Bufalin）是一种C-24类固醇，在C-17处带有一个α-吡喃酮环。它存在于蟾蜍（Venenum Bufonis）的毒液腺和皮肤中。蟾蜍灵是强心类固醇，是蟾蜍的地高辛类成分。 应用： 蟾蜍灵已被用于： 测试其对核因子κB（NF-κB）细胞和肿瘤坏死因子-α（TNF-α）刺激的类风湿关节炎成纤维样滑膜细胞（RAFLS）的侵袭和激活的影响。 作为软骨细胞中的核受体共激活因子3（NCOA3）抑制剂。 用于测试其在对吉非替尼有抗药性的肺癌细胞（NCI-H460）中的抗转移作用。 Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis. Bufalin is a cardiotonic steroid and is digoxin-like component of Chan Su. Application： Bufalin has been used: To test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs). As a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes. To test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib.
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Bufalin
Dangerous GoodsCAS number：465-21-4 molecular formula：C24H34O4
overview
compound introduction
Specs
| Chinese alias | 3β,14-二羟基-5β | 20 (22)-丁二烯醇内酯,5β | 20 (22)-丁二烯醇内酯-3β,14-二醇 | ||
| English alias | 3-methoxy-2-pyridinone | Bufalin: Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)-, | bufalin | Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)- | UNII-U549S98QLW | (3beta,5beta,10alpha,17alpha)-3,14-dihydroxybufa-20,22-dienolide | BRD-K63606607-001-02-6 | | ||
| CAS number | 465-21-4 | molecular formula | C24H34O4 |
| molecular weight | 386.52 g/mol | Exact mass | - |
| PSA | 66.800 Ų | logp | 3.200 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
Personal protective equipment：
Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges
RTECS：
EI2962500
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
465-21-4 | Bufalin.pdf
