属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.
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Imperatorin
Dangerous GoodsCAS number：482-44-0(DMSO) molecular formula：C16H14O4
overview
compound introduction
Specs
| Chinese alias | 前胡内酯 | 白芷乙素 | 前胡素 | 8-(3-甲基-2-丁烯氧基)补骨脂素 | 8-异戊烯氧基补骨脂素 | 白茅苷 | 9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮 | ||
| English alias | NCGC00095209-05 | SCHEMBL50437 | 9-(3-Methyl-2-butenyloxy)-7-oxofuro[3,2-g]chromene | 9-(3-Methyl-but-2-enyloxy)-furo[3,2-g]chromen-7-one | 9-(3-Methylbut-2-enyloxy)furo[3,2-g]chromen-7-one | HMS2218G08 | SDCCGMLS-0066373.P001 | HMS3885G06 | NCGC00095209- | ||
| CAS number | 482-44-0(DMSO) | molecular formula | C16H14O4 |
| molecular weight | 270.28 g/mol | Exact mass | 10mM in DMSO |
| PSA | 48.700 Ų | logp | 3.400 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
Signal word：
警告
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
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MSDS
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