Product Application： 4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
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4-Hydroxyquinazoline
Dangerous GoodsCAS number：491-36-1 molecular formula：C8H6N2O
overview
compound introduction
Specs
| Chinese alias | 4-喹唑酮 | 4-喹唑啉醇 | ||
| English alias | A7361 | 4-Oxoquinazoline | JPZ | 3-hydro-4-quinazolinone | CHEBI:91430 | HY-W018800 | BDBM27504 | DB12967 | HMS3413K17 | H0803 | InChI=1/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11) | 4-(3h)-quinazolinone | 4(3H)-Quinazolinone | 3H-Quinazolin-4- | ||
| CAS number | 491-36-1 | molecular formula | C8H6N2O |
| molecular weight | 146.15 g/mol | Exact mass | 10mM in DMSO |
| PSA | 41.500 Ų | logp | 0.7 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US)， Eyeshields， Gloves
RTECS：
VA2300000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
491-36-1 | 4-Hydroxyquinazoline.pdf
