compound introduction
(L)-脱氢抗坏血酸(DHA)是一种强效糖化剂，由抗坏血酸（维生素）氧化制得。体外研究表明，对于晶状体蛋白糖化反应，DHA的活性远超葡萄糖和果糖。因此，DHA是晚期糖化终产物(AGE)体内形成的关键前体。 DHA的固体为二聚体形式，在溶液中又呈单体形式。 应用 (L)-脱氢抗坏血酸可作为起始原料用于： 与2-甲羟基吲哚反应合成吡喃并[3,4-b]吲哚衍生物。 与间苯三酚通过立体选择性C-C键形成反应合成(−)-抗坏血酸间苯三酚。 (L)-Dehydroascorbic acid (DHA) is a potent glycation agent that is produced by the oxidation of ascorbic acid (vitamin C). In vitro studies revealed that DHA is significantly more reactive than glucose and fructose in the glycation of lens proteins. Thus, DHA could be a critical precursor for the in vivo formation of advanced glycation end products (AGEs). DHA is a dimer when it is solid, but when it is dissolved in a solution, it becomes a monomer.
