CAS number：157-03-9 molecular formula：C6H9N3O3
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity.
| Chinese alias | 6-重氮-5-氧代-L-正亮氨酸 | ||
| English alias | (L)-DON | NSC 7365 | (2S)-2-amino-6-diazo-5-oxohexanoic acid | (2S)-2-amino-6-diazo-5-oxo-hexanoic acid | EX-A1965 | (S)-2-Amino-6-diazo-5-oxocaproic acid | diazooxonorleucine | NCI7365 | CHEBI:138889 | NCGC00013078 | 6-Diazo-5-oxo-L-norleucine, crystalli | ||
| CAS number | 157-03-9 | molecular formula | C6H9N3O3 |
| molecular weight | 171.15 g/mol | Exact mass | 10mM in Water |
| PSA | 82.400 Ų | logp | -3.500 |
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