p-Aminophenylmercuric acetate 是一种有机汞基质金属蛋白酶 (MMP) 激活剂。p-Aminophenylmercuric acetate 通过攻击蛋白质巯基或诱导半胱氨酸转换反应，参与 MMP-8 的激活和抑制。p-Aminophenylmercuric acetate 促进了 β 纤维素素前体 (pro-BTC) 脱落。p-Aminophenylmercuric acetate 影响阿片类受体与其激动剂和拮抗剂的结合。 p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor . In Vitro p-Aminophenylmercuric acetate (APMA) (0-30 µM; 20 min) decreases the apparent number of dihydromorphine binding sites and increases the sensitivity of agonist binding to the inhibitory effects of sodium in rat brain homogenate. p-Aminophenylmercuric acetate (0.5 mM; 30 min) activates the MMP-2 and MMP-9. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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p-Aminophenylmercuric acetate（APMA）
Dangerous GoodsCAS number：6283-24-5 molecular formula：C8H9HgNO2
overview
compound introduction
Specs
| Chinese alias | 4-乙酸汞基苯胺 | APMA | ||
| English alias | p-Aminophenylmercuric Acetate - CAS 6283-24-5 - Calbiochem | Mercury, (acetato-O)(4-aminophenyl)- | Mercury, (acetato-.kappa.O)(4-aminophenyl)- | acetoxymercurianiline | FT-0617597 | 4-Aminophenylmercury acetate | 1,3-Bis(2,4-diaminophenoxy)propane 4HCl, | ||
| CAS number | 6283-24-5 | molecular formula | C8H9HgNO2 |
| molecular weight | 351.75 g/mol | Exact mass | - |
| PSA | 52.300 Ų | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS09
Signal word：
Danger
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误
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