硫代乙酸 (TAA) 可在新型亚磺酰基脲有机催化剂存在下，与硝基烯烃发生对映体选择性加成，形成手性 1，2-氨基硫醇衍生物。该方法已成功地用于抗真菌药物硫康唑的合成。 双官能团胺硫脲催化不对称 Michael 加成反应，生成硫酯。 不对称 1,6-共轭加成反应 对位 -醌甲烷在手性磷酸催化剂存在下生成手性含硫二苯基甲烷型化合物。 甲基丙烯酰胺与手性反式-2,5-二取代吡咯烷助剂的共轭加成形成手性 β-巯基羧酸衍生物。 硫代乙酸是将巯基引入有机分子的试剂。 Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. A reagent for introduction of the thiol group into organic molecules. Thioacetic acid (TAA) can undergo: • Enantioselective addition to nitroalkenes to form chiral 1,2-aminothiol derivatives in the presence of a novel sulfinyl urea organocatalyst. This method has been successfully employed in the synthesis of antifungal drug, sulconazole. • Asymmetric Michael addition reaction with chalcones in the presence of a bifunctional amine thiourea catalyst to form synthetically useful thioesters. • Asymmetric 1,6-conjugate addition with para-quinone methides in the presence of a chiral phosphoric acid catalyst to form chiral sulfur-containing diphenylmethane-type compounds. • Conjugate addition to methacrylamides with chiral trans-2,5-disubstituted pyrrolidine auxiliaries to form chiral β-mercaptocarboxylic acid derivatives. Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. A reagent for introduction of the thiol group into organic molecules.
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Thioacetic acid
Dangerous GoodsCAS number：507-09-5 molecular formula：C2H4OS
overview
compound introduction
Specs
| Chinese alias | 乙硫羟酸 | 硫代醋酸 | ||
| English alias | A11392 | Thiacetic acid | AKOS015995385 | Kyselina thiooctova [Czech] | Potassium thioacetate | Thioacetic acid, 96% | C01857 | Acetic acid, thio- | J-520441 | MFCD00004853 | ethanethioic O-acid | Ethanethioic S-acid | MeCOSH | EINECS 208-063-8 | Thionoac | ||
| CAS number | 507-09-5 | molecular formula | C2H4OS |
| molecular weight | 76.12 g/mol | Exact mass | ≥95% |
| PSA | 18.100 Ų | logp | 0.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS05 , GHS07 , GHS02
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒 H314: 造成严重的皮肤灼伤和眼睛损伤 H302: 吞食有害 H318: 造成严重的眼睛损伤 H225: 高度易燃的液体和蒸气 H317: 可能引起皮肤过敏反应
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P233: 保持容器密闭。 P240: 地面/粘结容器和接收设备 P264: 处理后要彻底洗手。 P
WGK Germany：
3
Personal protective equipment：
Faceshields， full-face respirator (US)， Gloves， Goggles， multi-purpose combination respirator cartridge (US)， type ABEK (EN14387) respirator filter
RTECS：
AJ5600000
UN Number：
2436
General hazardous chemicals：
一般危化品
Packing Group：
II
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
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MSDS
Found 1 shareMSDS
507-09-5 | thioacetic acid | thioacetic acid
