compound introduction
C18 神经酰胺 (d18：1/18：0) 合成由神经酰胺合成酶 (CER) 1 和 5 催化。它是细胞膜的组成部分，而与不饱和神经酰胺相比，它的凝胶形成能力低 C18 神经酰胺（d18:1/18:0）已用于： 诱导 Manduca 胚胎细胞系（MRRL-CH1）中细胞凋亡 。其用作采用液相色谱-质谱法检测肝组织中神经酰胺的量的标准品，目的是抑制发生β-葡糖脑苷脂酶（GCase）突变的人胚肾细胞（HEK29）中的神经酰胺酶。 C18 Ceramide (d18:1/18:0) synthesis is catalyzed by ceramide synthase (CERS) 1 and 5. It is a component of cellular membrane and has low gel forming ability compared to unsaturated ceramide C18 Ceramide (d18:1/18:0) has been used: · to induce apoptosis in Manduca embryonic cell line (MRRL-CH1) · as a standard to quantify ceramide from liver tissue using liquid chromatography-mass spectrometry · to inhibit ceramidase in human embryonic kidney cells (HEK29) with β-glucocerebrosidase (GCase) mutation
