Ozone

Poison Gas

Breathing: Fresh air; 100% O2

EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice. INHALATION: Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably by mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice.

Not combustible but enhances combustion of other substances. Many reactions may cause fire or explosion. Risk of fire and explosion on contact with combustible substances.

Fireproof if in building. Separated from all substances. Cool.

In case of fire in the surroundings, use appropriate extinguishing media. Combat fire from a sheltered position.

Eyes, respiratory system

0.1 to 1 umol/mol will cause acute toxic effects. 40 nmol/mol will cause long term lung problems. Pulmonary edema developed in welders who had a severe acute exposure to an estimated 9 ppm ozone plus other air pollutants.

Wear face shield or eye protection in combination with breathing protection.

Dangerous fire ... risk in contact with organic materials.

At acute levels, ozone is an irritant and lachrymator. At chronically low doses (~40 nmol/mol) there is a great deal of evidence to show that ground level ozone can harm lung function and irritate the respiratory system. Long-term exposure to ozone and the pollutants that produce it is linked to premature death, asthma, bronchitis, heart attacks and other cardiopulmonary problems. Long-term exposure to ozone has been shown to increase risk of death from respiratory illness. An 18-year study on 450,000 people in the US revealed that those living in cities with high ozone levels such as Houston or Los Angeles had an over 30% increased risk of dying from lung disease. Both acute and chronic exposures to ozone can negatively impact the barrier function of the lung, and these exposures can i...

Ozone is highly toxic via inhalation or by contact of liquid to skin, eyes, or mucous membranes. It is capable of causing acute to chronic lung damage, burns, and death or permanent injury. Ozone can be toxic at a concentration of 100 ppm for 1 minute. Ozone is capable of causing death from pulmonary edema. It increases sensitivity of the lungs to bronchoconstrictors and allergens, increases susceptibility to and severity of lung bacterial and viral infections. (EPA, 1998)

Oxidizing Agents, Strong

ACGIH Carcinogen - Not Classifiable.

Inhalation

NO open flames, NO sparks and NO smoking. NO contact with combustible substances. Closed system, ventilation, explosion-proof electrical equipment and lighting.

Like phosgene and nitrogen dioxide, ozone is classified as less soluble relative to more soluble irritant inhalants like ammonia and chlorine. The less soluble vapors are more likely to cause potentially fatal pulmonary edema without the signs of severe upper respiratory injury. (See Comments for phosgene.) [LaDou, p. 564] Ozone is fibrogenic to the lungs in the context of an acute inhalation exposure complicated by bronchiolitis obliterans.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Cold-insulating gloves.

In the fume hood, wastes to be slowly released to air.

Flammability: Nonflammable Gas, but a powerful oxidizer.

The gas is heavier than air.

Ozone is a strong oxidant and reacts directly with organic double bonds. When ozone breaks down to dioxygen it gives rise to oxygen free radicals, which are highly reactive and capable of damaging many organic molecules. Moreover, it is believed that the powerful oxidizing properties of ozone may be a contributing factor of inflammation. When inhaled, ozone reacts with compounds lining the lungs to form specific, cholesterol-derived metabolites that are thought to facilitate the build-up and pathogenesis of atherosclerotic plaques. These metabolites have been confirmed as naturally occurring in human atherosclerotic arteries and are categorized into a class of secosterols termed atheronals, generated by ozonolysis of cholesterol's double bond to form a 5,6 secosterol. Ozone has also bee...

Strong Oxidizing Agent

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation.

REACTION BETWEEN ATOMIC OXYGEN & MOL OXYGEN RESULTS IN FORMATION OF OZONE, THE PRINCIPAL OXIDIZING AGENT OF PHOTOCHEMICAL SMOG. FURTHER REACTIONS INVOLVE OZONE & REACTIVE HYDROCARBONS (OLEFINS) TO PRODUCE MANY PRODUCTS, NATURE OF WHICH IS NOT YET FULLY KNOWN.

Eye First Aid: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Susceptible people can be adversely affected by ozone levels as low as 40 nmol/mol. In the EU, the current target value for ozone concentrations is 120 µg/m³ which is about 60 nmol/mol. In the US the recommended EPA standard is 75 nmol/mol.

OZONE is a propellant; ignites upon contact with alcohols, amines, ammonia, beryllium alkyls, boranes, dicyanogen, hydrazines, hydrocarbons, hydrogen, nitroalkanes, powdered metals, silanes, or thiols [Bretherick 1979. p.174]. Aniline in a atmosphere of ozone produces a white galatinous explosive ozobenzene [Mellor 1:911. 1946-47]. A mixture of ether and ozone forms aldehyde and acetic acid and a heavy liquid, ethyl peroxide, an explosive [Mellor 1:911. 1946-47]. Severe explosions occur attempting to form tribromic octaoxide from bromine and ozone [Mellor 2, Supp. 1:748. 1956]. Mixtures of ozone and dinitrogen pentaoxide are flammable or explosive [Mellor 8, Supp. 2:276. 1967]. Ozone and ethylene react explosively [Berichte 38:3837]. Nitrogen dioxide and ozone react with the evolution o...

Exposure of 0.1 to 1 μmol/mol produces headaches, burning eyes and irritation to the respiratory passages. Exposure to 10 ppm ozone will cause pulmonary edema. Low doses act as a depressant and will induce sleep in certain individuals.

Store in well-ventilated, cool, dark places. Detached storage is preferred. Avoid storage near combustible materials.

STRICT HYGIENE!

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Inhalation Acute Reference Concentration Reference: CALEPA

Use ventilation, local exhaust or breathing protection.

Isolate area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Workers handling liquid ozone should wear protective equipment designed for exposure to cryogenic liquid. (EPA, 1998)

No rapid reaction with air. No rapid reaction with water.

This substance may be hazardous to the environment. Special attention should be given to plants.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

No indication of carcinogenicity (not listed by IARC) (L135). Tests in mice found no carcinogenic effect (A15094).

FOUND IN ATMOSPHERE IN VARYING PROPORTIONS (ABOUT 0.05 PPM @ SEA LEVEL), SINCE IT IS PRODUCED CONTINUOUSLY INTHE OUTER LAYERS OF THE ATMOSPHERE BY THE ACTION OF SOLAR UV RADIATION ON THE OXYGEN OF THE AIR.

OSHA Highly Hazardous Chemicals, Toxics and Reactives: Note: Ozone in quantities at or above above 100lb presents a potential for a catastrophic event as a toxic or reactive highly hazardous chemical.

Important additional information about respirator selection

Preclude from exposure those personnel with pulmonary diseases.

Simultaneous, high resolution measurements of ozone (O3), NO, CO, dew point temp, and UV flux obtained during the NASA Global Tropospheric Experiment Chemical Instrumentation Test and Evaluation (GTE/CITE l) spring 1984 airborne field exercise over the eastern North Pacific Ocean were analyzed. The mid tropospheric O3 mixing ratio averaged about 48 + or - 15 parts per billion by volume (ppbv). Statistical analysis of the high resolution data indicates the existence of two O3 sources: one related to the downward transport of ozone- rich air from the upper troposphere and stratosphere and the other to the transport of O3-rich air from the continents.

TLV-TWA (Time Weighted Average): Heavy work: 0.05 ppm (0.10 mg/m³), Moderate work: 0.08 ppm (0.16 mg/m³), Light work: 0.10 ppm (0.20 mg/m³) [1995]

Repeated or prolonged inhalation of the gas may cause effects on the lungs.

Reactive agents - 3rd degree

The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. This may result in impaired vigilance and performance. Inhalation of the gas may cause lung oedema. The effects may be delayed. The liquid may cause frostbite.

Treatment is supportive, similar to that for smoke inhalation and chlorine

TWA 0.1 ppm (0.2 mg/m3) See Appendix G

PAC-3: 5.0 [ppm]

C 0.1 ppm (0.2 mg/m3)

CRITICAL TEMP: -12.1 °C; CRITICAL PRESSURE: 53.8 ATM

Measurements from the eastern north Pacific stratocumulus regime have been used to study components of the regional ozone budget. The surface destruction rate was determined by eddy correlation of ozone and vertical velocity measured during 8 flights of a low flying aircraft. Significant variability (2580 to 6460 s/m) was found in the measured surface resistance; it was partially correlated with friction velocity but appears to have other controlling influences as well. The mean resistance was 4190 + or - 840 s/m, which is higher (slower destruction) than most previous estimates for seawater. Flux and mean measurements throughout the marine boundary layer were used to estimate the net rate of in situ photochemical production/destruction of ozone. Averaged over the flights, ozone concn w...

... FOUND ... AROUND SOURCES OF X-RAYS AND UV RAYS, ELECTRIC ARCS (WELDING AND SPECTROGRAPHIC EQUIPMENT, FOR EXAMPLE), MERCURY VAPOR LAMPS, ULTRA-BILLION-VOLT LINEAR ACCELERATORS AND ELECTRICAL DISCHARGES IN GENERAL.

MAK (Maximale Arbeitsplatz Konzentration): carcinogen category: 3

Gas irritates the upper respiratory system strongly.

/Other/ incompatabilities: Alkenes, aromatic compounds, rubber, dicyanogen, dinitrogen tetroxide, 4-hydroxy-4-methyl-1,6-heptadiene, nitrogen trichloride, stibine, tetrafluorohydrazine.

See: 10028156