三（2-羧乙基）膦盐酸（TCEP.HCl）是一种非挥发性的固体。它是一种强还原剂。它可通过在回流的HCl水溶液中对三（2-氰基乙基）膦进行酸水解而合成。它具有多种生物学应用，例如多种肽和蛋白质中二硫键的体内及体外还原。1 TCEP可用作多种重金属离子如Zn(II), Cd(II), Pb(II)以及Ni(II)的螯合剂。 TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. TCEP Hydrochloride has been observed to reduce DHA in a solution of EDTA and metaphosphoric acid, and used to conduct proteolysis and Hydrogen/Deuterium exchange. Binding studies demonstrate that TCEP Hydrochloride does not bind Hg2+, and its binding efficacy to NF-κB-DNA has been tested in vitro. Reagent for the selective reduction of disulfides in water. Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications. When basified, this water-soluble ligand allows for simple removal of ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture.
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Tris(2-carboxyethyl)phosphine hydrochloride(TCEP HCl)
Dangerous GoodsCAS number：51805-45-9 molecular formula：C9H15O6P·HCl
overview
compound introduction
Specs
| Chinese alias | 三(2-羧乙基)磷盐酸盐 | 三(2-甲酰乙基)膦盐酸盐 | 三(2-羰基乙基)磷盐酸盐 | ||
| English alias | TCEP HCl | TCEP | Propanoic acid, 3,3',3''-phosphinylidynetris-, hydrochloride (1:1) | EN300-1724932 | Propanoic acid, 3,3',3''-phosphinidynetris-, hydrochloride | H49AAM893K | tris-(2-carboxyethyl)phosphine hydrochloride | Tris(2-carboxyethyl)phosphine h | ||
| CAS number | 51805-45-9 | molecular formula | C9H15O6P·HCl |
| molecular weight | 286.65 g/mol | Exact mass | 10mM in DMSO |
| PSA | 112.000 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS05
Signal word：
Danger
Hazard Statement：
H314: 造成严重的皮肤灼伤和眼睛损伤
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P363: 再次使用之前，请清洗受污染的衣物。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟
WGK Germany：
2
Personal protective equipment：
Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter
UN Number：
3261
Packing Group：
II
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
51805-45-9 | TCEP, Hydrochloride.pdf
