Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.Amitriptyline hydrochloride is a tricyclic antidepressant drμg. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors. Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Amitriptyline Hydrochloride
Dangerous GoodsCAS number：549-18-8 molecular formula：C20H23N · HCl
overview
compound introduction
Specs
| Chinese alias | 盐酸阿米替林 | 盐酸阿密替林 | N,N-二甲基-3-[10,11-二氢-5H-二苯并(a,b)环庚三烯-5-亚基]-1-丙胺盐酸盐 | ||
| English alias | 5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride | AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH] | Amyline | Novoprotect | SR-01000003046 | Tryptizol retard | AMITRIPTYLINE HYDROCHLORIDE (EP IMPURITY) | Larozy | ||
| CAS number | 549-18-8 | molecular formula | C20H23N · HCl |
| molecular weight | 313.86 g/mol | Exact mass | ≥98% |
| PSA | 3.200 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS08 , GHS09 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H319: 引起严重眼睛刺激 H301: 吞咽会中毒 H302: 吞食有害 H318: 造成严重的眼睛损伤 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H370: 对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P263
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS：
HO9450000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
549-18-8 | Amitriptyline hydrochloride.pdf
