Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been sμggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathwayA sequiterpene lactone that inhibits telomerase Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway A sequiterpene lactone that inhibits telomerase
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Costundide
Dangerous GoodsCAS number：553-21-9 molecular formula：C15H20O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | MFCD00210262 | HMS3677B19 | Costunlide | NSC106404 | Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)- | AKOS015969714 | Costunolide | SCHEMBL92714 | (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8 | ||
| CAS number | 553-21-9 | molecular formula | C15H20O2 |
| molecular weight | 232.32 g/mol | Exact mass | 分析标准品 |
| PSA | 26.300 Ų | logp | 2.100 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H317: 可能引起皮肤过敏反应
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
WGK Germany：
3
RTECS：
LY4270000
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
553-21-9 | Costunolide.pdf
