8-iso Prostaglandin F2α

8-异前列烷是通过花生四烯酸的非酶自由基催化的过氧化作用而产生的生物活性异前列腺素。该化合物已在大鼠的肺和肾中显示出有效的血管收缩活性，其作用似乎是通过对血栓烷受体的激动剂活性介导的。然而，有证据表明存在单独的和不同的异前列腺素受体。8-异前列烷也是3T3细胞和血管平滑肌细胞中的促分裂原，可能在肺氧中毒中起作用。研究表明，可以将8-异前列烷浓度的测定用作氧化应激的非侵入性指标，并且该化合物可以在体内用作氧化应激的信号分子。8-异前列烷是TXA2R的激活剂。 8-epi PGF2α is a biologically active isoprostane produced by the non-enzymatic free radical catalyzed peroxidation of arachidonic acid . This compound has demonstrated potent vasoconstriction activity in rat lung and kidney where its effects seem to be mediated through agonist activity at thromboxane receptors; however, evidence exists for a separate and distinct isoprostane receptor. 8-epi PGF2α is also a mitogen in 3T3 cells and in vascular smooth muscle cells, and may play a role in pulmonary oxygen toxicity. Research has suggested that measurement of 8-epi PGF2α concentration could be used as a non-invasive indicator of oxidative stress, and that this compound may act|in vivo|as a signaling molecule of oxidative stress. 8-epi-Prostaglandin F2α is an activator of TXA2R.

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