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Ailanthone

Dangerous Goods

CAS number：981-15-7    molecular formula：C20H24O7

overview
Specs
numbering system
physicochemical properties
Safety information
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overview

compound introduction

Ailanthone (AIL, Δ13-Dehydrochaparrinone) 是一种来自臭椿Ailanthus altissima的天然通过抗肝癌(HCC)成分，可通过降低 cyclins 和 CDKs 的表达、提高 p21 和 p27 的表达来诱导G0/G1期细胞周期阻滞。Ailanthone 可触发DNA损伤，其特征为 ATM/ATR 通路的激活。Ailanthone 可在Huh7细胞中诱导线粒体介导、涉及 PI3K/AKT 信号通路的细胞凋亡。Ailanthone 也是全长 Androgen Receptor (AR-FL)和组成型活性截断AR剪接变体(AR-Vs, AR1-651)的抑制剂，对应的IC50值分别为69 nM和309 nM。

Specs

Chinese alias(1β,11β,12α)-11,20-环氧-1,11,12-三羟基吡啶3,13(21)-二烯-2,16-二酮 | 臭椿酮 | 臭椿苦酮
English aliaso13-Dehydrochaparrinoneo13-Dehydrochaparrinone | 2H-1,11c-(Epoxymethano)phenanthro(10,1-bc)pyran-5,10(3H,6ah)-dione, 1,3a,4,7,7a,11,11a,11b-octahydro-8,11a-beta-dimethyl-3-methylene-1-alpha,2-beta,11-beta-trihydroxy- | Ailanthone, >=98% (HPLC) | HY-N1943
CAS number981-15-7molecular formulaC20H24O7
molecular weight376.4 g/molExact mass≥98%(HPLC)
PSA113.000 Ųlogp-1.100

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
RTECS：
KT0930000

Production methods and uses

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MSDS

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