1,2,3,4,5,6-Hexabromocyclohexane

Dangerous Goods

CAS number：1837-91-8 molecular formula：C6H6Br6

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts. A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

Specs

Chinese alias	1,2,3,4,5,6-六溴环己烷
English alias	1,2,3,4,5,6-Hexabrom-cyclohexan (I(2)-Form) \| NSC-41797 \| Benzene hexabromide \| JAK2 Inhibitor II - CAS 1837-91-8 \| s5902 \| FT-0633875 \| T71979 \| Cyclohexane, 1,2,3,4,5,6-hexabromo- \| SCHEMBL459442 \| MFCD00059127 \| HY-107594 \| JAK2 Inhibitor II \| 1,2,3,4,
CAS number	1837-91-8	molecular formula	C6H6Br6
molecular weight	557.54 g/mol	Exact mass	2mM in DMSO
PSA	0.000 Å²	logp	5.000

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H319: 引起严重眼睛刺激 H302: 吞食有害

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。