Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy . Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties In Vitro Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells. Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells. Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner. Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells. Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil IC50& Target:PPARγ
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Falcarindiol
CAS number：55297-87-5 molecular formula：C17H24O2
overview
compound introduction
Specs
| Chinese alias | 镰叶芹二醇 | ||
| English alias | 1,9-Heptadecadiene-4,6-diyne-3,8-diol | SCHEMBL40936 | (E)-Heptadeca-1,9-dien-4,6-diyne-3,8-diol | Falcarindiol | heptadeca-1,9-dien-4,6-diyne-3,8-diol | (9E)-heptadeca-1,9-dien-4,6-diyne-3,8-diol | 1,9-Heptadecadiene-4,6-diyne-3,8-diol, (3S,8S,9Z)- | AKO | ||
| CAS number | 55297-87-5 | molecular formula | C17H24O2 |
| molecular weight | 260.399 g/mol | Exact mass | ≥99% |
| PSA | 40.500 Ų | logp | 4.400 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
