Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions throμgh all three receptors. Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors.
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Agomelatine
Dangerous GoodsCAS number：138112-76-2 molecular formula：C15H17NO2
overview
compound introduction
Specs
| Chinese alias | N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺 | ||
| English alias | Agomelatine [INN:BAN] | F0001-2383 | HMS3654B07 | N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide | Q-102507 | Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]- | Agomelatine [INN] | N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide | PDSP1_001305 | GTPL198 | Melitor | ||
| CAS number | 138112-76-2 | molecular formula | C15H17NO2 |
| molecular weight | 243.3 g/mol | Exact mass | - |
| PSA | 38.300 Ų | logp | 2.7 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H400: 对水生生物有剧毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304
WGK Germany：
3
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
