8-Bromoadenosine 3′,5′-cyclic monophosphate

应用： 8-溴腺苷3′,5′-环一单磷酸用于： 处理 H295R细胞，作为 CYP19诱导的阳性对照； 作为可渗透膜的cAMP类似物，研究其对短路电流(Isc)的影响； 研究其作为分化诱导剂，分化诱导Whalton′s胶质来源间充质干细胞（WJ-MSC）的潜力。 生理/生化： 8-溴腺苷-3′,5′-环单磷酸是一种细胞渗透性cAMP类似物，比cAMP具有更强的磷酸二酯酶水解抵抗性。8-溴腺苷-3′,5′-环单磷酸能激活蛋白激酶A、抑制生长、减少增殖、增加分化并诱导培养细胞的凋亡。在平板培养肝细胞的过程中，添加8-溴腺苷3′,5′-环-单磷酸（8-溴-cAMP），有助于增加获得β-肾上腺素受体。比 cAMP 更抗磷酸二酯酶水解的细胞通透性 cAMP 类似物。 Application： 8-Bromoadenosine 3′,5′-cyclic monophosphate has been used: to treat H295R cells as positive controls for CYP19 induction as a membrane permeable cAMP analog to study its effect on short-circuit current (Isc) to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs). Biochemical/physiological effects: 8-Bromoadenosine 3′,5′-cyclic monophosphate is a cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. 8-Bromoadenosine 3′,5′-cyclic monophosphate activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. 8-bromo-adenosine 3′,5′-cyclic monophosphate (8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors. Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP.

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