扁枝衣二酸是某些地衣产生的次级代谢产物。分子模型研究表明，地衣酸通过与FAS-II酶蛋白表面的变构位点结合而间接起作用。在人肝细胞和癌细胞以及斑马鱼模型中评估了扁枝衣二酸的潜在毒性。这项研究表明，扁枝衣二酸作为一种抗菌和抗疟原虫剂可能具有治疗和预防的潜力。己烯酸也已经评估了其对人淋巴细胞的杀伤和抗增殖作用，但是研究表明，在所施用的浓度下，扁枝衣二酸并未显示出对淋巴细胞增殖的统计学显着抑制作用。 Evernic acid is a secondary metabolite produced by some species of lichen. Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of FAS-II enzymes. Potential toxicity of Evernic acid was assessed in human hepatocyte and cancer cells as well as in a zebrafish model. This study indicates there could be therapeutic and prophylactic potential of Evernic acid as an antibacterial and antiplasmodial agent. Evernic acid has also been evaluated for clastogenic and antiproliferative effects on human lymphocytes, however the investigation showed Evernic acid did not show a statistically significant inhibitory effect on lymphocyte cell proliferation at the applied concentrations.
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Evernic acid
CAS number：537-09-7 molecular formula：C17H16O7
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | Evernic acid | HY-121362 | 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-.beta.-resorcylate | 2EQ5W5403J | MFCD00045824 | 4-((4-Methoxy-6-methylsalicyloyl)oxy)-6-methylsalicylic acid | NCGC00246189-01 | 2, 4-methoxy-, 4-ester with 6-methyl-.beta.-r | ||
| CAS number | 537-09-7 | molecular formula | C17H16O7 |
| molecular weight | 332.305 g/mol | Exact mass | ≥98% |
| PSA | 113.000 Ų | logp | 4.000 |
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Safety information
RTECS：
GP4195000
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