L-Selenomethionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine.A compound shown to increase expression of glutathione peroxidase L-Selenomethionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine. A compound shown to increase expression of glutathione peroxidase
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L-Selenomethionine
Dangerous GoodsCAS number：3211-76-5 molecular formula：CH3SeCH2CH2CH(NH2)CO2H
overview
compound introduction
Specs
| Chinese alias | (S)-2-氨基-4-(甲基硒)丁酸 | 硒-L-蛋氨酸 | ||
| English alias | L-(+)-Selenomethionine | L(+)-Selenomethionine | Megavite RX | CHEBI:30021 | Butanoic acid, 2-amino-4-(methylseleno)-, (S)- | SR-01000395830 | (2S)-2-amino-4-(methylseleno)butanoic acid | 2-Amino-4-(methylselenyl)butyrate | NCGC00181044-01 | Pharmakon1600 | ||
| CAS number | 3211-76-5 | molecular formula | CH3SeCH2CH2CH(NH2)CO2H |
| molecular weight | 196.11 g/mol | Exact mass | ≥97%(HPLC) |
| PSA | 63.300 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS08 , GHS09
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒 H331: 吸入会中毒 H373: 通过长时间或反复暴露对器官造成损害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭
WGK Germany：
3
RTECS：
EK7713840
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
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MSDS
Found 1 shareMSDS
3211-76-5 | S-Selenomethionine.pdf
