Cladribine是一种腺苷脱氨酶抑制剂，作用于U266， RPMI8226，和MM1.S细胞，IC50分别约为2.43 μM， 0.75 μM，和0.18 μM。 最大吸收波长265(EtOH aq.) nm Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
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Cladribine
Dangerous GoodsCAS number：4291-63-8 molecular formula：C10H12ClN5O3
overview
compound introduction
Specs
| Chinese alias | 克拉利宾 | 2-氯-2'-脱氧腺嘌呤核苷 | 2-氯-9-(2-脱氧-β-D-呋喃阿拉伯糖基)腺嘌呤 | ||
| English alias | CdA | Mavenclad (TN) | Q414030 | RWJ-26251-000 | Tox21_110834 | Cladribine (JAN/USP/INN) | NSC-05014 | SW197746-4 | 2-Chloro-2'-deoxy-beta-adenosine | BC164318 | HMS3715F17 | MFCD00153939 | MLS000759397 | Mylinax | DTXSID8022828 | MLS000028377 | NCGC00254 | ||
| CAS number | 4291-63-8 | molecular formula | C10H12ClN5O3 |
| molecular weight | 285.69 g/mol | Exact mass | - |
| PSA | 119.000 Ų | logp | 0.8 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
RTECS：
AU7357560
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
4291-63-8 | Cladribine, United States Pharmacopeia (USP)Reference Standard.pdf
