溶于水，溶于乙酸，微溶于丙酮；不溶于乙醇、乙醚和苯 己二酸二酰肼是一种同型双功能交联剂，对醛具有特异性。因而腙键相对稳定。在高碘酸盐氧化后，己二酸二酰肼常用于位点特异性连接各类糖蛋白，如抗体。低pKa的酰肼可避免与伯胺竞争，因此可在pH 5.0条件下进行氧化和偶联。 应用 己二酸二酰肼已用于： 制备反应性预混物，合成多孔生物材料 交联甲基丙烯酸化硫酸软骨素 (MA-CS) 涂层，利用基于碳二亚胺的化学方法生产和表征甲基丙烯酸化硫酸软骨素磁性纳米粒子(MA-CS MNPs) 使用Abberior STARNHS酯染料共价标记鼠李糖脂、绿脓杆菌素和万古霉素 Homobifunctional cross-linking reagent that is specific for aldehydes resulting in relatively stable hydrazone linkages. This is commonly used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines. Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride. General description Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. This results in relatively stable hydrazone linkages. Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
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Adipic acid dihydrazide（ADH）
Dangerous GoodsCAS number：1071-93-8 molecular formula：C6H14N4O2
overview
compound introduction
Specs
| Chinese alias | 己二酰肼 | ||
| English alias | Adipic acid dihydrazide, >=98% (titration) | AI3-22640 | Hexanedioic dihydrazide | J-660023 | Q-200600 | Q4682936 | Adip dihydr | AKOS000267183 | VK98I9YW5M | A801603 | Z56812730 | Adipic acid dihydrazide, purum, >=97.0% (NT) | FT-0621914 | Hexanedioic ac | ||
| CAS number | 1071-93-8 | molecular formula | C6H14N4O2 |
| molecular weight | 174.2 g/mol | Exact mass | ≥99%(HPLC) |
| PSA | 110.000 Ų | logp | -2.1 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09
Signal word：
Warning
Hazard Statement：
H411: 对水生生物有毒并具有长期持续影响 H317: 可能引起皮肤过敏反应
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P391: 收集溢出物
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
AV1400000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
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