3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts. 3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts. Affinity label for cysteine residues; Cross-linker between nucleic acids and proteins
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Bromopyruvic acid
Dangerous GoodsCAS number：1113-59-3 molecular formula：C3H3BrO3
overview
compound introduction
Specs
| Chinese alias | 3-溴丙酮酸 | ||
| English alias | AS-16146 | B1153 | 3-bromopyruvic acid | bromo-2-oxopropanoic acid | bromopyruvic acid | Bromopyruvic acid, >=97.0% (T) | J-650255 | 3-bromopyruvate | BPV | J-511892 | 3-bromo-2-oxopropanoic acid | AKOS015892643 | AM84337 | EINECS 214-206-5 | 3-BP | 3-BrP | ||
| CAS number | 1113-59-3 | molecular formula | C3H3BrO3 |
| molecular weight | 166.96 g/mol | Exact mass | 10mM in DMSO |
| PSA | 54.400 Ų | logp | 0.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS05
Signal word：
Danger
Hazard Statement：
H314: 造成严重的皮肤灼伤和眼睛损伤
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P310: 立即致电解毒中心或医生。
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS：
UZ0840000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
1113-59-3 | Bromopyruvic acid.pdf
