为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定，水溶液在4℃的稳定期为3天。 主要活性成分是尿激酶的低分子量形式，由 2,000 道尔顿的 A 链和 30,400 道尔顿的 B 链通过巯基键连接而成。 产品 应用： 人肾细胞产生的尿激酶已被用作消化混合物的成分，用于三维纤维蛋白培养。也用于纤溶酶原激活试验 。 生理学机理： 尿激酶可促进肾肿瘤细胞的增殖。尿激酶是一种蛋白酶，能裂解纤溶酶原形成纤溶酶。与细胞表面受体 (uPAR) 结合，在组织重塑过程中调节细胞粘附和迁移，并激活细胞内信号通路。尿激酶由三个结构域组成：与表皮生长因子同源的氨基末端结构域通过中央圈形区结构域连接到羧基端的蛋白酶结构域。 Physical form Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol Physical properties High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
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尿激酶
Dangerous GoodsCAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 079X63S3DU | CAMBENDAZOLE [MART.] | Cambendazole 100 microg/mL in Acetonitrile | MFCD00864552 | QZWHWHNCPFEXLL-UHFFFAOYSA-N | Camdan (TN) | NOE [French] | Equiben | J-690273 | SMR003475014 | DTXSID0046852 | isopropyl N-(2-thiazol-4-yl-1H-benzimidazol-5-yl | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | - |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
WGK Germany：
3
RTECS：
OB8900000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
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