溶于水、乙醇。溶液为橙黄色带绿色荧光。pH值为8.4～10.4则无荧光。能镶嵌于两个相邻的碱基对之间，使部分双螺旋DNA松开，该两个碱基对的距离拉大一倍。这样的DNA复制过程中，会使DNA链增加或缺失一个碱基，造成移码突变。Colour Index Number 46005 用作荧光指示剂，肿瘤细胞及细菌、核酸染色剂及移码突变的诱变剂。 吖啶橙是一种荧光色素，吖啶橙激发滤光片波长488nm。阻断滤光片波长515nm。吖啶橙与细胞中DNA和RNA结合量存在差别，可发出不同颜色的荧光（即着色特异性），这是由于DNA是个高度聚合物，吸收荧光物质的位置较少，发绿色荧光，而RNA聚合度低，能和荧光物质结合的位置多，故发红色荧光。 用途 适合 检测凝胶电泳分离的核酸 荧光和落射荧光显微镜 流式细胞术分析线粒体和溶酶体 凋亡研究中的DNA染色 吖啶橙是一种细胞可渗透的异染色荧光阳离子染料，可嵌入 DNA 和 RNA，用于荧光和表观显微镜检测。吖啶橙染料已被用于通过流式细胞术分析线粒体和溶酶体含量，表征多药耐药性以及检测大鼠胸腺细胞凋亡过程中线粒体质量的变化。 Acridine Orange hemi (zinc chloride) salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. This dye is also an inhibitor of RNA polymerase. Fluorescent dye that stains DNA and RNA Application Suitable for detection of nucleic acids separated by gel electrophoresis fluorescence and epifluorescence microscopy analysis of mitochondria and lysosomes by flow cytometry DNA staining in apoptosis studies Acridine Orange, a cell-permeable metachromatic fluorescent cationic dye that intercalates DNA and RNA, is used in fluorescence and epiflouresence microscopy. Acridine Orange dye has been used to analyze mitochondria and lysosomal content by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes.
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Acridine Orange hemi(zinc chloride) salt
Dangerous GoodsCAS number：10127-02-3 molecular formula：C17H20ClN3 · HCl · 1/2ZnCl2
overview
compound introduction
Specs
| Chinese alias | 碱性橙 14 | 3,6-双(二甲基氨基)吖啶氯化物半(氯化锌盐) | 3,6-双(二甲基氨基)吖啶盐酸盐 氯化锌复盐 | 吖啶橙GNY | 吖啶橙3RX | ||
| English alias | C.I. 46005 | Euchrysin GNY | Euchrysine 3RX | AKOS027250830 | N,N,N inverted exclamation marka,N inverted exclamation marka-Tetramethylacridine-3,6-diamine monohydrochloride compd. with zinc dichloride | BasicOrange14 | DTXSID20906035 | N,N,N',N'-Tetramet | ||
| CAS number | 10127-02-3 | molecular formula | C17H20ClN3 · HCl · 1/2ZnCl2 |
| molecular weight | 369.96 g/mol | Exact mass | 适用于电泳 |
| PSA | 19.400 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H341: 怀疑引起遗传缺陷
Statement of Preventive Measures：
P405: 密闭存放 P501: 将内容物/容器处理到。。。 P281: 根据需要使用个人防护设备。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
Production methods and uses
No production method and use information yet
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downstream information
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MSDS
Found 1 shareMSDS
10127-02-3 | Acridine Orange hemi(zinc chloride) salt.pdf
